Inhibition of Cx43/ZO‐1 Interaction Improves Gap Junction Intercellular Communication and Reduces Connexon Activity
نویسندگان
چکیده
منابع مشابه
Assembly of gap junction intercellular communication channels.
788 with a lipidlprotein molar ratio of 100:1, a value close to that found in most biological membranes [21]. The data show that the calculation of distances between sites within the monomer of a membrane protein of a cross-sectional diameter of 5 nm based only from FET efficiency measurements is largely speculative in most cases in native biological membranes. Because the contribution of FET t...
متن کاملRegulation of hematopoiesis by gap junction-mediated intercellular communication.
Gap junctions are intercellular channels formed by individual structural units known as connexins (Cx) that allow the intercellular exchange of small molecules between cells. The presence of Cx protein in bone marrow and thymic stromal cells and the demonstration that these cells are functionally coupled have led to the hypothesis that groups of stromal cells in the bone marrow and thymus form ...
متن کاملInhibition of gap junction-mediated intercellular communication by TNF-alpha in cultured human corneal fibroblasts.
PURPOSE Keratocytes are connected to each other by gap junctions, which mediate intercellular communication and contribute to maintenance of corneal homeostasis. The possible effect of tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine, on gap junctional intercellular communication (GJIC) in cultured human corneal fibroblasts was examined. METHODS GJIC activity was measured by obse...
متن کاملInhibition of Gap Junction–Mediated Intercellular Communication by TNF- in Cultured Human Corneal Fibroblasts
RESULTS. TNFinduced a timeand concentration-dependent decrease in GJIC activity in human corneal fibroblasts. Immunofluorescence analysis revealed that TNFreduced the level of specific staining for Cx43 at sites of contact between adjacent cells. Immunoblot analysis detected four specific Cx43 bands, one corresponding to the nonphosphorylated form of the protein and three corresponding to phosp...
متن کاملReduction in gap junction intercellular communication promotes glioma migration
Glioblastoma Multiforme (GBM), an aggressive form of adult brain tumor, is difficult to treat due to its invasive nature. One of the molecular changes observed in GBM is a decrease in the expression of the gap junction protein Connexin43 (Cx43); however, how a reduction in Cx43 expression contributes to glioma malignancy is still unclear. In this study we examine whether a decrease in Cx43 prot...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.1028.1